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1

Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity

Antoni R. Blaazer, Jos H.M. Lange, Martina A.W. van der Neut, Arie Mulder, Femke S. den Boon, Taco R. Werkman, Chris G. Kruse, Wytse J. Wadman

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 456 KB

english, 2011

2

Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB 1 Cannabinoid Receptor Antagonists

Lange, Jos H. M., van Stuivenberg, Herman H., Coolen, Hein K. A. C., Adolfs, Tiny J. P., McCreary, Andrew C., Keizer, Hiskias G., Wals, Henri C., Veerman, Willem, Borst, Alice J. M., de Looff, Wouter,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 353 KB

english, 2005

3

Research, Ethics and Risk in the Authoritarian Field ||

Glasius, Marlies, de Lange, Meta, Bartman, Jos, Dalmasso, Emanuela, Lv, Aofei, Del Sordi, Adele, Michaelsen, Marcus, Ruijgrok, Kris

Year:

2018

Language:

english

File:

PDF, 1.24 MB

english, 2018

4

Low implicit self-esteem and dysfunctional automatic associations in social anxiety disorder

Glashouwer, Klaske A., Vroling, Maartje S., de Jong, Peter J., Lange, Wolf-Gero, de Keijser, Jos

Journal:

Journal of Behavior Therapy and Experimental Psychiatry

Year:

2013

Language:

english

File:

PDF, 556 KB

english, 2013

5

Does guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis

Karyotaki, Eirini, Ebert, David Daniel, Donkin, Liesje, Riper, Heleen, Twisk, Jos, Burger, Simone, Rozental, Alexander, Lange, Alfred, Williams, Alishia D., Zarski, Anna Carlotta, Geraedts, Anna, van

Journal:

Clinical Psychology Review

Year:

2018

Language:

english

File:

PDF, 780 KB

english, 2018

6

Design, Synthesis and Biological Activity of Rigid Cannabinoid CB1 Receptor Antagonists.

Axel Reinhard Stoit, Jos Hubertus Maria Lange, Arnold Peter den Hartog, Eric Ronken, Koos Tipker, Herman Heinrich van Stuivenberg, Jessica Adriana Rigtje Dijksman, Henri Cornelis Wals, Chris Gerrit Kr

Journal:

Year:

2003

File:

PDF, 144 KB

2003

7

Ruphos-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates

Adri van den Hoogenband, Jos H.M. Lange, Jan Willem Terpstra, Melle Koch, Gerben M. Visser, Martin Visser, Ties J. Korstanje, Johann T.B.H. Jastrzebski

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 172 KB

english, 2008

8

Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists

Jos H.M. Lange, Chris G. Kruse

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 241 KB

english, 2005

9

The social aspects of food biotechnology: a European view

David Barling, Huib de Vriend, Jos A Cornelese, Bo Ekstrand, Edwin F.F Hecker, John Howlett, Jørgen H Jensen, Tim Lang, Sue Mayer, Kirsten B Staer, Rob Top

Journal:

Environmental Toxicology and Pharmacology

Year:

1999

Language:

english

File:

PDF, 163 KB

english, 1999

10

Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel 3,4-Diarylpyrazolines as Potent and Selective CB 1 Cannabinoid Receptor Antagonists

Lange, Jos H. M., Coolen, Hein K. A. C., van Stuivenberg, Herman H., Dijksman, Jessica A. R., Herremans, Arnoud H. J., Ronken, Eric, Keizer, Hiskias G., Tipker, Koos, McCreary, Andrew C., Veerman, Wil

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 693 KB

english, 2004

11

Network based requirement specification

Lutters, Eric, Dankers, Winnie, Oude Luttikhuis, Ellen, de Lange, Jos

Journal:

CIRP Annals - Manufacturing Technology

Year:

2014

Language:

english

File:

PDF, 542 KB

english, 2014

12

Atomic stacking and van-der-Waals bonding in GeTe–Sb2Te3 superlattices

Momand, Jamo, Lange, Felix R.L., Wang, Ruining, Boschker, Jos E., Verheijen, Marcel A., Calarco, Raffaella, Wuttig, Matthias, Kooi, Bart J.

Journal:

Journal of Materials Research

Year:

2016

Language:

english

File:

PDF, 1.20 MB

english, 2016

13

Fatigue is associated with altered monitoring and preparation of physical effort in patients with chronic fatigue syndrome

van der Schaaf, Marieke E., Roelofs, Karin, de Lange, Floris P., Geurts, Dirk EM., van der Meer, Jos WM., Knoop, Hans, Toni, Ivan

Journal:

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Year:

2018

Language:

english

File:

PDF, 1.88 MB

english, 2018

14

ANNALS EXPRESS: Clinically inappropriate post-hoc exclusion of study participants from test accuracy calculations: The ROMA score, an example from a recent NICE diagnostic assessment.

Lang, Shona, Armstrong, Nigel, Deshpande, Sohan, Ramaekers, Bram, Grimm, Sabine, de Kock, Shelley, Kleijnen, Jos, Westwood, Marie Elaine

Journal:

Annals of Clinical Biochemistry

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

15

ChemInform Abstract: A Straightforward Synthetic Approach for Roxindole.

Jos H. M. Lange, Johannes C. de Jong, Hans J. Sanders, Geb M. Visser, Chris G. Kruse

Journal:

Year:

1999

File:

PDF, 28 KB

1999

16

ChemInform Abstract: Regioselective Aminomethylations of Bicyclic Phenols.

Jos Lange, Sonja Hoogeveen, Willem Veerman, Henri Wals

Journal:

Year:

2000

File:

PDF, 32 KB

2000

17

ChemInform Abstract: Rapid Microwave-Enhanced Synthesis of 4-Hydroxyquinolinones under Solvent-Free Conditions.

Jos H. M. Lange, Peter C. Verveer, Stefan J. M. Osnabrug, Geb M. Visser

Journal:

Year:

2001

File:

PDF, 29 KB

2001

18

ChemInform Abstract: Microwave-Enhanced Goldberg Reaction: A Novel Route to N-Arylpiperazinones and N-Arylpiperazinediones.

Jos H. M. Lange, Lovina J. F. Hofmeyer, Floris A. S. Hout, Stefan J. M. Osnabrug, Peter C. Verveer, Chris G. Kruse, Rolf W. Feenstra

Journal:

Year:

2002

File:

PDF, 29 KB

2002

19

Novel 3,4-Diarylpyrazolines as Potent Cannabinoid CB1 Receptor Antagonists with Lower Lipophilicity.

Jos H. M. Lange, Herman H. van Stuivenberg, Willem Veerman, Henri C. Wals, Bob Stork, Hein K. A. C. Coolen, Andrew C. McCreary, Tiny J. P. Adolfs, Chris G. Kruse

Journal:

Year:

2006

File:

PDF, 24 KB

2006

20

ChemInform Abstract: Synthesis, SAR and Intramolecular Hydrogen Bonding Pattern of 1,3,5-Trisubstituted 4,5-Dihydropyrazoles as Potent Cannabinoid CB1 Receptor Antagonists.

Jos H. M. Lange, Martina A. W. van der Neut, Arnold P. den Hartog, Henri C. Wals, Jan Hoogendoorn, Herman H. van Stuivenberg, Bernard J. van Vliet, Chris G. Kruse

Journal:

Year:

2010

File:

PDF, 36 KB

2010

21

ChemInform Abstract: A Simple, Base-Free Preparation of S-Aryl Thioacetates as Surrogates for Aryl Thiols.

Adri van den Hoogenband, Jos H. M. Lange, Raymond P. J. Bronger, Axel R. Stoit, Jan Willem Terpstra

Journal:

Year:

2011

File:

PDF, 32 KB

2011

22

ChemInform Abstract: A Novel Atom-Efficient, One-Pot Synthesis of Sulfonylguanidines and Sulfamoylguanidines.

Jos H. M. Lange, Stefan Verhoog, Hans J. Sanders, Arnold von Loevezijn, Chris G. Kruse

Journal:

Year:

2011

File:

PDF, 35 KB

2011

23

ChemInform Abstract: Novel Indole and Azaindole (Pyrrolopyridine) Cannabinoid (CB) Receptor Agonists: Design, Synthesis, Structure—Activity Relationships, Physicochemical Properties and Biological Activity.

Antoni R. Blaazer, Jos H. M. Lange, Martina A. W. van der Neut, Arie Mulder, Femke S. den Boon, Taco R. Werkman, Chris G. Kruse, Wytse J. Wadman

Journal:

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

24

ChemInform Abstract: The First Examples of Rhodium-Catalyzed 1,4-Conjugate Addition Reactions of Arylboronic Acids with Ethenesulfonamides.

Hicham Zilaout, Adri van den Hoogenband, Jelle de Vries, Jos H. M. Lange, Jan Willem Terpstra

Journal:

Year:

2012

File:

PDF, 30 KB

2012

25

Cross-national comparison and validation of the Alzheimer's Disease Assessment Scale: results from the European Harmonization Project for Instruments in Dementia (EURO-HARPID)

Frans R. Verhey, Peter Houx, Natascha van Lang, Felicia Huppert, Gabriella Stoppe, Jos Saerens, Peter Böhm, Luc de Vreese, Arto Nordlund, Peter P. DeDeyn, Mirco Neri, Jordi Peña-Casanova, Anders Walli

Journal:

International Journal of Geriatric Psychiatry

Year:

2004

Language:

english

File:

PDF, 94 KB

english, 2004

26

Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies

Jos H.M. Lange, Martina A.W. van der Neut, Henri C. Wals, Gijs D. Kuil, Alice J.M. Borst, Arie Mulder, Arnold P. den Hartog, Hicham Zilaout, Wouter Goutier, Herman H. van Stuivenberg, Bernard J. van V

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 335 KB

english, 2010

27

Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity

Jos H.M. Lange, Herman H. van Stuivenberg, Willem Veerman, Henri C. Wals, Bob Stork, Hein K.A.C. Coolen, Andrew C. McCreary, Tiny J.P. Adolfs, Chris G. Kruse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 211 KB

english, 2005

28

Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

Jos H.M. Lange, Arnold P. den Hartog, Martina A.W. van der Neut, Bernard J. van Vliet, Chris G. Kruse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 303 KB

english, 2009

29

Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists

Jos H.M. Lange, Martina A.W. van der Neut, Arnold P. den Hartog, Henri C. Wals, Jan Hoogendoorn, Herman H. van Stuivenberg, Bernard J. van Vliet, Chris G. Kruse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 423 KB

english, 2010

30

Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern

Jos H.M. Lange, Martina A.W. van der Neut, Alice J.M. Borst, Mahmut Yildirim, Herman H. van Stuivenberg, Bernard J. van Vliet, Chris G. Kruse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 355 KB

english, 2010

31

Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists

Jos H.M. Lange, Amos Attali, Martina A.W. van der Neut, Henri C. Wals, Arie Mulder, Hicham Zilaout, Ate Duursma, Hans H.M. van Aken, Bernard J. van Vliet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

32

A novel synthesis of N-(piperidin-4-yl)-1,3-dihydroindol-2-one via an intramolecular Pd-catalyzed amination

Adri van den Hoogenband, Jack A.J. den Hartog, Jos H.M. Lange, Jan Willem Terpstra

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 250 KB

english, 2004

33

An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles

Adri van den Hoogenband, Jos H.M. Lange, Wouter I. Iwema-Bakker, Jack A.J. den Hartog, Jord van Schaik, Rolf W. Feenstra, Jan Willem Terpstra

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 104 KB

english, 2006

34

An efficient synthesis of 4-bromo-N-substituted oxindoles by an intramolecular copper-catalyzed amidation reaction

Adri van den Hoogenband, Jos H.M. Lange, Jack A.J. den Hartog, Remco Henzen, Jan Willem Terpstra

Journal:

Tetrahedron Letters

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

35

A straightforward synthesis of 1,3-dichloro-5,8-dihydroisoquinoline by consecutive Stille cross-coupling and metathesis reactions

Adri van den Hoogenband, Jack A.J. den Hartog, Nancy Faber-Hilhorst, Jos H.M. Lange, Jan Willem Terpstra

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

36

A simple, base-free preparation of S-aryl thioacetates as surrogates for aryl thiols

Adri van den Hoogenband, Jos H.M. Lange, Raymond P.J. Bronger, Axel R. Stoit, Jan Willem Terpstra

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 1.94 MB

english, 2010

37

An expedient atom-efficient synthesis of the cannabinoid CB1 receptor inverse agonist ibipinabant

Jos H.M. Lange, Hans J. Sanders, Jeroen van Rheenen

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 314 KB

english, 2011

38

A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines

Jos H.M. Lange, Stefan Verhoog, Hans J. Sanders, Arnold van Loevezijn, Chris G. Kruse

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 371 KB

english, 2011

39

Representative assessment of long bone shaft biomechanical properties: an optimized testing method

Jos A.M Bramer, Robbert H Barentsen, Maarten vd Elst, Elly S.M.de Lange, Peter Patka, Henk J.Th.M Haarman

Journal:

Journal of Biomechanics

Year:

1998

Language:

english

File:

PDF, 228 KB

english, 1998

40

Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions

Jos H.M Lange, Peter C Verveer, Stefan J.M Osnabrug, Geb M Visser

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 62 KB

english, 2001

41

Microwave-enhanced Goldberg reaction: a novel route to N-arylpiperazinones and N-arylpiperazinediones

Jos H.M Lange, Lovina J.F Hofmeyer, Floris A.S Hout, Stefan J.M Osnabrug, Peter C Verveer, Chris G Kruse, Rolf W Feenstra

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

42

Rapid quantification of delavirdine, a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with fluorescence detection

Agnes I. Veldkamp, Rolf P.G. van Heeswijk, Richard M.W. Hoetelmans, Pieter L. Meenhorst, Jan W. Mulder, Joep M.A. Lange, Jos H. Beijnen

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1999

Language:

english

File:

PDF, 105 KB

english, 1999

43

Quantitative determination of efavirenz (DMP 266), a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection

Agnes I Veldkamp, Rolf P.G van Heeswijk, Pieter L Meenhorst, Jan W Mulder, Joep M.A Lange, Jos H Beijnen, Richard M.W Hoetelmans

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1999

Language:

english

File:

PDF, 88 KB

english, 1999

44

A straightforward synthetic approach for roxindole

Jos H.M Lange, Johannes C de Jong, Hans J Sanders, Geb M Visser, Chris G Kruse

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 105 KB

english, 1999

45

Effectiveness of screening preschool children for amblyopia: a systematic review

Christine Schmucker, Robert Grosselfinger, Rob Riemsma, Gerd Antes, Stefan Lange, Wolf Lagrèze, Jos Kleijnen

Journal:

BMC Ophthalmology

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

46

Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives

Jos H. M. Lange, Chris G. Kruse

Journal:

The Chemical Record

Year:

2008

Language:

english

File:

PDF, 273 KB

english, 2008

47

Langetermijneffecten van de Interapy Burnout-behandeling: de resultaten van een follow-upstudie na ruim tweeënhalf jaar

Jos Verstraten, Alfred Lange, Eva Lith

Journal:

Directieve Therapie

Year:

2006

Language:

dutch

File:

PDF, 113 KB

dutch, 2006

48

Diagnostic accuracy of vision screening tests for the detection of amblyopia and its risk factors: a systematic review

Christine Schmucker, Robert Grosselfinger, Rob Riemsma, Gerd Antes, Stefan Lange, Wolf Lagrèze, Jos Kleijnen

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2009

Language:

english

File:

PDF, 199 KB

english, 2009

49

Mid-21st century climate and weather extremes in Cyprus as projected by six regional climate models

Panos Hadjinicolaou, Christos Giannakopoulos, Christos Zerefos, Manfred A. Lange, Stelios Pashiardis, Jos Lelieveld

Journal:

Regional Environmental Change

Year:

2011

Language:

english

File:

PDF, 909 KB

english, 2011

50

Two novel syntheses of the histamine H3 antagonist thioperamide

Jos H.M. Lange, Henri C. Wals, Adri van den Hoogenband, Aalt van de Kuilen, Jack A.J. den Hartog

Journal:

Year:

1995

Language:

english

File:

PDF, 457 KB

english, 1995

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